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Attenuated agents often give rise to a long-lasting immunity.

A) True
B) False

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Recombinant vaccines and inactivated vaccines typically require several shots to be effective.

A) True
B) False

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Agglutination tests can be used to diagnose diseases caused by


A) bacteria.
B) hormones.
C) fungi.
D) viruses.
E) All of the choices are correct.

F) B) and D)
G) A) and D)

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The term vaccination


A) is a general term that would include the process of variolation.
B) was coined by Jenner.
C) was coined by Pasteur.
D) comes from the Latin for cow,vacca.
E) is a general term that would include the process of variolation,was coined by Pasteur AND comes from the Latin for cow,vacca.

F) D) and E)
G) None of the above

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The effectiveness of DNA vaccines stems from the effective production of antibodies against the naked DNA molecule.

A) True
B) False

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Monoclonal antibodies obtained from a hybridoma provide


A) a large amount of an antibody that is specific for a particular epitope.
B) a single antibody that recognizes many epitopes.
C) many epitopes that recognize a specific antibody.
D) a large number of B cells.

E) None of the above
F) A) and B)

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Agglutination reactions utilize particles rather than molecules.

A) True
B) False

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The virus originally used for vaccination against smallpox is named


A) vaccinia.
B) cowpox.
C) rubella.
D) herpes.

E) All of the above
F) A) and B)

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Inactivated immunizing agents are prepared by treatment with


A) alcohol.
B) phenol.
C) formalin.
D) histamine.

E) A) and D)
F) A) and C)

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Precipitation occurs when


A) antigen combines with antigen.
B) antibody combines with antibody.
C) antibody combines with antigen.
D) antibody combines with antigen at optimal proportions.

E) A) and B)
F) C) and D)

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Injection of a single antigen usually results in production of


A) antibody to a single epitope.
B) an antibody that recognizes several epitopes.
C) additional antigen.
D) a number of antibodies each recognizing a different epitope.

E) B) and D)
F) All of the above

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Blood for transfusion is frequently tested for HIV by using the


A) complement fixation test.
B) agglutination test.
C) ELISA method.
D) Ouchterlony test.

E) B) and C)
F) A) and C)

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Which of the following methods allows monitoring of the progressive destruction of CD4 T cells during an HIV infection by tagging the cells with specific antibodies to CD4 surface proteins and measuring their concentrations in serum?


A) Western blot
B) ELISA
C) FACS
D) Latex beads agglutination
E) FA test on a microscope slide

F) B) and D)
G) A) and B)

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Which type of vaccine has been used in place of inactivated whole cell vaccine?


A) Acellular subunit
B) Whole cell attenuated
C) Adjuvant
D) Toxin

E) All of the above
F) A) and B)

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A poorly understood,yet promising type of vaccine that causes the host to produce microbial antigens for a short time involves the use of


A) subunits.
B) DNA.
C) alum.
D) toxoids.
E) glycoproteins.

F) D) and E)
G) B) and D)

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Which of the following tests allows the separation of cells according to their sizes,densities,and surface markers tagged by specific fluorescent antibodies?


A) Western blot
B) ELISA
C) Fluorescence-activated cell sorter
D) FA test on a microscope slide

E) B) and C)
F) None of the above

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Immunological tests may determine the presence of


A) only antibody.
B) only antigen.
C) antigen or antibody.
D) neither antibody nor antigen.

E) All of the above
F) None of the above

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The procedure developed by the Chinese to protect against smallpox was called


A) Oriental poxination.
B) humoral immunity.
C) variolation.
D) naturally acquired immunity.

E) B) and C)
F) A) and D)

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Would antibodies produced by a patient in response to infection be monoclonal,or polyclonal?


A) Since the infection is from only a single agent/microbe,the antibodies would be monoclonal.
B) Since a single pathogen has multiple antigens,and each antigen has multiple epitopes,the responding antibodies to a whole pathogen would be polyclonal.
C) Since the pathogen would most likely mutate slightly during the infection (producing different epitopes) ,the responding antibodies would be polyclonal.
D) Since the pathogen would acquire and modify self-antigens during the infectious process,the antibodies produced during the response would be polyclonal.

E) B) and C)
F) C) and D)

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