Question 1

All of the following are typical monitoring tests performed after a kidney transplant except

Accepted Answer

A)  C4D staining and histological analysis
B)  Serum creatinine level
C)  Serum complement level
D)  Urinary outputE) B) and C)
F) C) and D)

Question 2

The HLA class II genetic region is divided into which subregions?

Accepted Answer

A)  DOA,DOB,DMA,DMB
B)  DP,DO/DM,DQ,DR
C)  HLA-A,HLA-B,HLA-C
D)  MIC-A,MIC-BE) B) and C)
F) A) and C) B

Question 3

Which HLA class of molecules is used in solid phase assays?

Accepted Answer

A)  Class I only
B)  Class II only
C)  Class III only
D)  Class I or IIE) A) and B)
F) C) and D)

Question 4

In humans the major histocompatibility complex (MHC) is also called the _____ system.

Accepted Answer

A)  DRA
B)  HAL
C)  HLA
D)  MICE) C) and D)
F) A) and B)

Question 5

Which of the following is the correct term used for "multiple genes expressed in an individual that produce similar products"?

Accepted Answer

A)  Polymorphic
B)  Polygenic
C)  Polymerase
D)  PseudogeneE) All of the above
F) A) and B)

Question 6

When matching a recipient and donor for hematopoietic progenitor cell (HPC) transplant,how many alleles should be identified in the donor and recipient?

Accepted Answer

A)  8
B)  10
C)  12
D)  16E) A) and B)
F) A) and D)

Question 7

Which of the following methods is typically used to crossmatch a recipient's serum with donor lymphocytes?

Accepted Answer

A)  Flow cytometry
B)  Sequence-specific primer typing
C)  Signal transduction
D)  Solid phase assayE) B) and D)
F) B) and C)

Question 8

The SSO (sequence-specific oligonucleotide) probe hybridization method

Accepted Answer

A)  begins with amplification of the target DNA
B)  determines the nucleotide sequence of the entire exon
C)  employs primer pairs that are specific for unique sequences within an exon
D)  uses two rounds of polymerase chain reaction (PCR) E) None of the above
F) A) and B)

Question 9

When matching a recipient and potential donor for kidney transplant,all of the following antigens should be identified except

Accepted Answer

A)  HLA-A
B)  HLA-B
C)  HLA-DQ
D)  HLA-DRE) None of the above
F) A) and D)

Question 10

What is the best description of a CREG?

Accepted Answer

A)  Group of alleles on the same chromosome that are often inherited together
B)  Group of antigens that all react with an antibody directed against a common epitope
C)  Group of antigens resulting from alleles that are independently segregated
D)  Group of HLA antibodies that react with a particular epitope common to multiple bacteriaE) A) and D)
F) B) and D)

Question 11

How many DRB genes exist in the human population?

Accepted Answer

A)  1
B)  5
C)  9
D)  10E) C) and D)
F) A) and D)

Question 12

All of the following describe the adaptive immune system except

Accepted Answer

A)  Also known as the natural immune system
B)  Consists of antigen presenting cells
C)  Displays an anamnestic response
D)  Is involved in allograft rejectionE) A) and B)
F) None of the above A

Question 13

A crossmatch using autologous lymphocytes can indicate if which of the following is present?

Accepted Answer

A)  Alloantibodies
B)  Autoantibodies
C)  IgG
D)  IgME) A) and B)
F) A) and C)

Question 14

Which type of transplant is frequently used to treat genetic and acquired dysfunction of the bone marrow?

Accepted Answer

A)  Bone
B)  B lymphocyte cell
C)  Hematopoeitic progenitor cell
D)  LiverE) A) and B)
F) A) and C)

Question 15

Which chromosome carries the genes for the HLA system?

Accepted Answer

A)  1
B)  3
C)  6
D)  9E) B) and C)
F) A) and D)

Question 16

All of the following are true about HLA class I molecules except

Accepted Answer

A)  Are expressed only on antigen presenting cells
B)  Includes a 45 kDa α glycoprotein heavy chain
C)  Includes a 12 kDa β-2 microglobulin light chain
D)  Has a peptide-binding cleft that reacts with short peptidesE) A) and B)
F) None of the above

Question 17

If all possible alleles have the same nucleotide sequence in the exons coding for the peptide-binding domains,the string is reported as the possible allele with the lowest number followed by a capital

Accepted Answer

A)  A
B)  D
C)  G
D)  PE) All of the above
F) B) and D)

Question 18

Which of the following are molecules produced and secreted by activated cells?

Accepted Answer

A)  Cytokines
B)  Cytometries
C)  Cytosines
D)  CytosolsE) B) and C)
F) A) and C) A

Question 19

Which antigen would not be considered a Class I antigen?

Accepted Answer

A)  HLA-A
B)  HLA-B
C)  HLA-C
D)  HLA-DE) A) and D)
F) None of the above

Question 20

When discussing the 2010 naming convention,all of the following statements are true except

Accepted Answer

A)  The first set of numbers is called the allele family.
B)  The second set of numbers is assigned in order of the allele's discovery.
C)  The third set of numbers differentiates alleles that have different DNA sequences in the noncoding areas of the gene.
D)  The fourth set of numbers refers to differences in the untranslated end pieces of DNA.E) C) and D)
F) B) and D)

Exam 18: Human Histocompatibility

All of the following are typical monitoring tests performed after a kidney transplant except

Correct AnswerverifiedShow Answer

The HLA class II genetic region is divided into which subregions?

Correct AnswerverifiedB

Which HLA class of molecules is used in solid phase assays?

Correct AnswerverifiedShow Answer

In humans the major histocompatibility complex (MHC) is also called the _____ system.

Correct AnswerverifiedShow Answer

Which of the following is the correct term used for "multiple genes expressed in an individual that produce similar products"?

Correct AnswerverifiedShow Answer

When matching a recipient and donor for hematopoietic progenitor cell (HPC) transplant,how many alleles should be identified in the donor and recipient?

Correct AnswerverifiedShow Answer

Which of the following methods is typically used to crossmatch a recipient's serum with donor lymphocytes?

Correct AnswerverifiedShow Answer

The SSO (sequence-specific oligonucleotide) probe hybridization method

Correct AnswerverifiedShow Answer

When matching a recipient and potential donor for kidney transplant,all of the following antigens should be identified except

Correct AnswerverifiedShow Answer

What is the best description of a CREG?

Correct AnswerverifiedShow Answer

How many DRB genes exist in the human population?

Correct AnswerverifiedShow Answer

All of the following describe the adaptive immune system except

Correct AnswerverifiedA

A crossmatch using autologous lymphocytes can indicate if which of the following is present?

Correct AnswerverifiedShow Answer

Which type of transplant is frequently used to treat genetic and acquired dysfunction of the bone marrow?

Correct AnswerverifiedShow Answer

Which chromosome carries the genes for the HLA system?

Correct AnswerverifiedShow Answer

All of the following are true about HLA class I molecules except

Correct AnswerverifiedShow Answer

If all possible alleles have the same nucleotide sequence in the exons coding for the peptide-binding domains,the string is reported as the possible allele with the lowest number followed by a capital

Correct AnswerverifiedShow Answer

Which of the following are molecules produced and secreted by activated cells?

Correct AnswerverifiedA

Which antigen would not be considered a Class I antigen?

Correct AnswerverifiedShow Answer

When discussing the 2010 naming convention,all of the following statements are true except

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified
B

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
A

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
A

Correct Answer
verified

Correct Answer
verified