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Gluconeogenesis refers to synthesis of________and occurs in _______


A) triglycerides : adipose tissue
B) glucose : all organs
C) glucose : the liver
D) glycogen : the liver
E) fatty acids : adipose tissue

F) B) and D)
G) None of the above

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The sum of the thousands of chemical reactions that occur within the body is called


A) oxidation.
B) metabolism.
C) hydrolysis.
D) phosphorylation.
E) reduction.

F) A) and B)
G) C) and D)

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In a metabolic pathway, the enzyme working the slowest in that pathway is known as the_________ enzyme.


A) binding
B) inhibitor
C) rate -limiting
D) modulating
E) allosteric regulating

F) All of the above
G) B) and D)

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What process occurs within the inner mitochondrial membrane?


A) glycolysis
B) Krebs cycle
C) gluconeogenesis
D) glycogenesis
E) electron transport chain

F) C) and E)
G) D) and E)

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Where within the cell does glycolysis occur?


A) cytosol
B) nucleus
C) mitochondrial matrix
D) inner mitochondrial membrane
E) rough ER

F) A) and B)
G) C) and D)

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Chemiosmotic coupling refers to


A) coupling of the Krebs cycle to the electron transport chain.
B) chemical coupling between substrate and enzymes.
C) chemical coupling of each reaction within the mitochondria.
D) the transfer of a phosphate group from one molecule to another.
E) the harnessing of energy from the reactions of the electron transport chain to make ATP.

F) All of the above
G) C) and D)

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What is the strength of binding between an enzyme and substrate called?


A) enzyme -substrate complex
B) covalent modulator
C) peptide bond
D) ligand
E) affinity

F) A) and E)
G) B) and C)

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Decreasing temperatures will___________ the frequency of collisions between molecules, thereby___________the reaction rate.


A) not alter : increasing
B) not alter : not changing
C) increase : increasing
D) decrease : decreasing
E) increase : decreasing

F) B) and E)
G) A) and B)

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Several types of chemical reactions are involved in the process of metabolism. Provide a general description of these reactions: hydrolysis, condensation, phosphorylation, dephosphorylation, oxidation, and reduction reactions.

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Hydrolysis/condensation reactions involv...

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In terms of energy production, the Krebs cycle is significant because it


A) reduces the coenzymes NAD and FAD for oxidative phosphorylation.
B) produces acetylcoenzyme A for fatty acid synthesis.
C) breaks down glucose.
D) directly produces large amounts of ATP.
E) provides acetylcoenzyme A for glucose synthesis.

F) A) and B)
G) None of the above

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In a reduction reaction, which of the following is most likely added to the reactants? Reactions.


A) water
B) oxygen
C) electrons
D) neutrons
E) phosphate

F) C) and D)
G) A) and E)

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The enzyme carbonic anhydrase catalyzes the following reaction: CO2 + H2O -H2CO3, then H2CO3 dissociates reversibly to form H+ + HCO3 - When tissue becomes more active, carbon dioxide increases due to its production in ,__________ Causing hydrogen ion concentration to_________ .


A) the cytosol : decrease
B) the cytosol : increase
C) mitochondria : increase
D) mitochondria : decrease
E) both the cytosol and mitochondria : decrease

F) B) and E)
G) All of the above

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Molecules must have sufficient potential energy to overcome the _________and, thereby, allow the reaction to proceed.


A) activation energy barrier
B) mass action
C) transitional energy barrier
D) transformation state
E) kinetic energy

F) A) and B)
G) B) and D)

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Complete oxidation of 1 mole glucose produces 6 moles of water and 6 moles of carbon dioxide.

A) True
B) False

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Enzymes act as________to increase reaction rate.


A) an energy source
B) catalysts
C) intermediates
D) reactants
E) products

F) A) and E)
G) C) and D)

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Tony is about to participate in his first 10K run. One of his friends told him to make sure to "carbo load" and to take a niacin supplement before the race. Tony had heard the term "carbo loading" before but was not sure why it was necessary and had n why he would need a niacin supplement. He had been training for months and was confident that he would finish the race ea therefore, did not heed his friend's advice. On the day of the race, Tony was so excited it felt like he was flying through the first half of the race. Tony wanted to beat his current best time and was nearing the end of the race when he decided to pick up his pace to the finish line. Unfortunately, Tony became fatigued and had to walk to the finish line out of breath and with his muscles burning. -Refer to Scenario 3.1. Could Tony's excitement before the race have caused him to become fatigued toward the end of the race?


A) No; the body has many ways to produce energy and, therefore, never runs out.
B) Yes; his excitement created more demand for oxygen from his vital organs and tissues, therefore using up that oxygen to produce energy that he needed for the race.
C) No; the excess heat produced in his body would have sped up his reaction rates, causing him to run faster.
D) No; due to homeostatic mechanisms, metabolism remains constant at all times.
E) Yes; because of his excitement, his breathing rate increased and he probably hyperventilated before the race, causing him to be tired.

F) A) and D)
G) C) and D)

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When a substrate binds to a protein via weak interactions, the substrate is referred to as a


A) peptide bond.
B) ligand.
C) product.
D) modulator.
E) reactant.

F) B) and E)
G) B) and D)

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Which of the following statements about the law of mass action is FALSE?


A) The slope of a curve represents the rate of reaction; the greater the slope the faster the rate of reaction.
B) Equilibrium is reached when the concentration of reactant equals the concentration of product.
C) An increase in the concentration of reactants relative to products tends to push a reaction forward, and an increase in the concentration of products relative to reactants tends to push a reaction in reverse.
D) It is critical in physiological processes because concentrations of reactants and products in cells and body fluids constantly change.
E) After reaching equilibrium, more reactant is added, which causes the production of more product.

F) None of the above
G) C) and D)

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Identify the following chemical reaction by its type: Protein + H2O -Amino acids.


A) hydrolysis
B) oxidation
C) condensation
D) phosphorylation
E) reduction

F) C) and D)
G) B) and D)

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Before converting amino acids into intermediates for energy metabolism, they must first undergo


A) denaturation.
B) deamination.
C) depeptidization.
D) oxidation
E) detoxification.

F) A) and D)
G) A) and E)

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