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A.Describe two ways in which the immunoglobulins acting as antigen receptors on the surface of a mast cell differ from the immunoglobulins acting as the antigen receptors on the surface of a B cell. B.What is the essential difference in response of these two cell types when antigen binds to these surface immunoglobulins.

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A. (i)The immunoglobulin on a mast cell ...

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During a primary immune response IgM sometimes switches to IgE.Which of the following best describes the consequence of this early switch?


A) The B cell would switch again to IgG3.
B) The B cell would remain in the germinal center but would not differentiate into a plasma cell.
C) The B cell would die by apoptosis.
D) The IgE produced would have low affinity for antigen.

E) All of the above
F) B) and C)

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D

Why are antihistamines used to treat allergic rhinitis and allergic asthma? What symptoms of each disease,respectively,do they alleviate.

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Mast cells activated by inhaled allergen...

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The antigens that provoke hypersensitivity reactions are referred to as


A) T-independent antigens
B) superantigens
C) subunit vaccines
D) attenuated vaccines
E) allergens.

F) A) and B)
G) A) and C)

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A.Explain the importance of allergens having protease activity in the context of antigen-specific T-cell activation. B.Provide a specific example of a major allergen that has protease activity.

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A.Particles containing proteins that sti...

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The sheddase _____ cleaves FcεRII on the cell surface,resulting in the production of monomeric and trimeric forms of FcεRII.


A) cathepsin G
B) CR2
C) eotaxin
D) major basic protein
E) ADAM10.

F) B) and D)
G) C) and D)

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Anita Garcia,17 years old,and her roommate Rosa Rosario were celebrating a friend's birthday at a dessert buffet at a local restaurant when Anita developed acute dyspnea,and angioedema.She complained of an itchy rash,and then had difficulty swallowing.Rosa drove Anita to the emergency room two blocks away rather than wait for an ambulance.As they approached the hospital,Anita lost consciousness -What do you think Anita was suffering from? Given the circumstances in which the episode occurred,suggest a likely cause.

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Anita was suffering from acute anaphylac...

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All of the following are biological effects mediated by the products of mast cells except _____.


A) chemotaxis of neutrophils,eosinophils,and effector T cells
B) growth factor secretion
C) smooth muscle contraction
D) connective tissue remodeling
E) All of the above are mediated by mast cells.

F) B) and D)
G) D) and E)

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E

During the course of a successful desensitization process,the patient's antibodies will change from an _____isotype to an _____ isotype.


A) IgG4:IgE
B) IgE:IgM
C) IgA:IgM
D) IgG1:IgG4
E) IgE:IgG4.

F) B) and E)
G) C) and D)

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Explain briefly how penicillin initiates a type I hypersensitivity response.

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The reactive bond in the β-lactam ring o...

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Identify the mismatched pair.


A) TNF-α: immediate release from mast cells
B) mucosal mast cell production: T-cell immunodeficiencies
C) connective tissue mast cells: chymotryptase
D) lipid mediator: prostaglandins
E) leukotrienes: increase vascular permeability.

F) B) and D)
G) D) and E)

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Aspirin (acetyl salicylate) inhibits prostaglandin synthesis by binding irreversibly to prostaglandin synthase,the first enzyme in the _____ pathway.


A) cyclooxygenase
B) carboxypeptidase
C) metalloprotease
D) lipooxygenase
E) peroxidase.

F) C) and E)
G) A) and C)

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A.Describe in detail the mechanism responsible for mast-cell activation during a type I hypersensitivity reaction. B.What are the products of mast-cell activation?

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A.If an individual becomes sensitized to...

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Anita Garcia,17 years old,and her roommate Rosa Rosario were celebrating a friend's birthday at a dessert buffet at a local restaurant when Anita developed acute dyspnea,and angioedema.She complained of an itchy rash,and then had difficulty swallowing.Rosa drove Anita to the emergency room two blocks away rather than wait for an ambulance.As they approached the hospital,Anita lost consciousness.This medical emergency would most probably result in immediate _____ before any subsequent treatment.


A) subcutaneous injection of epinephrine
B) intravenous injection of corticosteroids
C) intravenous injection of antihistamine
D) intravenous injection of antibiotics
E) intravenous injection of a nonsteroidal anti-inflammatory drug.

F) A) and E)
G) C) and D)

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Which of the following directly inhibits the cyclooxygenase pathway by inhibiting the activity of prostaglandin synthase?


A) ADAM10
B) experimental anti-IgE
C) aspirin (acetyl salicylate)
D) chymotryptase
E) ADAM33.

F) B) and D)
G) B) and C)

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Match the mast cell product with its biological effect.

Premises
tryptase
histamine
TNF-α
CCL3
IL-4
Responses
chemotaxis
connective tissue matrix remodeling
activates endothelium
amplifies TH2-cell response
increases vascular permeability

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tryptase
connective tissue matrix remodeling
histamine
increases vascular permeability
TNF-α
activates endothelium
CCL3
chemotaxis
IL-4
amplifies TH2-cell response

Which of the following regarding FcεRI is false?


A) It is expressed on the surface of mast cells and basophils.
B) It is a low-affinity receptor involved in type I hypersensitivity reactions.
C) It binds to IgE in the absence of antigen.
D) It is a membrane-bound tetramer.
E) It contains signaling components that re activated following antigen cross-linking.

F) B) and E)
G) C) and D)

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Give three ways in which a susceptible person can help to minimize the risk of having an allergic reaction.

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(i)Avoid contact with allergens as much ...

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A.Explain how erythrocytes become coated with complement component C3b during an allergic reaction to penicillin. B.Why is this important to the mechanism by which IgE antibodies are produced?

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A.C3b becomes deposited on the cell surf...

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Which of the following are consequences of anaphylactic shock? (Select all that apply.)


A) smooth muscle contraction
B) immune complex deposition on blood vessels
C) loss of blood pressure
D) constriction of airways
E) complement activation.

F) D) and E)
G) B) and C)

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